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Trypanocidal diarylheptanoids from Aframomum letestuianum K. Schum (Zingiberaceae).

Author:
  • P Kamnaing
  • Apollinaire Tsopmo
  • E A Tanifum
  • M H K Tchuendem
  • P Tane
  • J F Ayafor
  • Olov Sterner
  • D Rattendi
  • M M Iwu
  • B Schuster
  • C Bacchi
Publishing year: 2003
Language: English
Pages: 364-367
Publication/Series: Journal of Natural Products
Volume: 66
Issue: 3
Document type: Journal article
Publisher: The American Chemical Society

Abstract english

Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4'-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4'-dihydroxyflavanone, 7-methoxy-3,5,4'-trihydroxyflavone, and 3,3',4',5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes. IC50 values in the range of 1-3 g/mL were found for compounds 3 and 5.

Keywords

  • Organic Chemistry

Other

Published
  • ISSN: 0163-3864
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

+46 46 222 82 13

+46 70 530 66 49

B127

Sölvegatan 27, Lund

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Professor

Centre for Analysis and Synthesis

+46 46 222 82 13

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