Bioactive alkenylphenols from Piper obliquum.
- Centre for Analysis and Synthesis
- Applied Microbiology
Publishing year: 2008
Publication/Series: Bioorganic & Medicinal Chemistry
Document type: Journal article
Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.
- Organic Chemistry
- Industrial Biotechnology
- ISSN: 0968-0896