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Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Author:
  • Ola Bergendorff
  • Kim Dekermendjian
  • Mogens Nielsen
  • Rudong Shan
  • Robin Witt
  • Jinglu Ai
  • Olov Sterner
Publishing year: 1997
Language: English
Pages: 1121-1124
Publication/Series: Phytochemistry
Volume: 44
Issue: 6
Document type: Journal article
Publisher: Elsevier

Abstract english

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.

Keywords

  • Dermatology and Venereal Diseases

Other

Published
  • ISSN: 0031-9422
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

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