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Antileishmanial metabolites from Trixis antimenorrhoea

Author:
  • Eliana Maldonado
  • Efrain Salamanca
  • Alberto Gimenez
  • Gloria Saavedra
  • Olov Sterner
Publishing year: 2014
Language: English
Pages: 281-286
Publication/Series: Phytochemistry Letters
Volume: 10
Document type: Journal article
Publisher: Elsevier

Abstract english

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Keywords

  • Chemical Sciences
  • Trixis antimenorrhoea
  • Nortrixane
  • Trixanolide
  • Antileishmanial
  • activity
  • Structural elucidation

Other

Published
  • ISSN: 1874-3900
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

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Faculty of Science

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