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An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Author:
  • Alberto Pagani
  • Federica Pollastro
  • Silvia Spera
  • Mauro Ballero
  • Olov Sterner
  • Giovanni Appendino
Publishing year: 2007
Language: English
Pages: 637-642
Publication/Series: Natural Product Communications
Volume: 2
Issue: 6
Document type: Journal article
Publisher: Natural Products Inc

Abstract english

A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

Keywords

  • Organic Chemistry
  • SERCA
  • Thapsia garganica
  • neohelmanthicin D
  • thapsivillosin J
  • thapsigargin
  • thapsigargicin

Other

Published
  • ISSN: 1934-578X
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

+46 46 222 82 13

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Professor

Centre for Analysis and Synthesis

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