Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Antioxidant secondary metabolites from Geranium lasiopus Boiss. & Heldr.

Author:
  • Didem Sohretoglu
  • Mahmut Koray Sakar
  • Suna Atasayar Sabuncuoglu
  • Hilal Ozgunes
  • Hayri Duman
  • Olov Sterner
Publishing year: 2012
Language: English
Pages: 1261-1264
Publication/Series: Natural Product Research
Volume: 26
Issue: 13
Document type: Journal article
Publisher: Taylor & Francis

Abstract english

Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (7) and quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 2)-beta-glucopyranoside (8)), two simple phenolic compounds (gallic acid (9) and its methyl ester (10)) and a hydrolysable tannin (pusilagin (11)). The structures of the compounds were elucidated by 1- and 2-dimensional NMR techniques (H-1, C-13, COSY, HMBC, HMQC) and ESI-TOF-MS spectrometry. Inhibitory effects on H2O2-induced lipid peroxidation in human red blood cells of the different extracts of G. lasiopus, as well as isolated compounds, were investigated. All tested compounds showed comparable or higher activity than that of ascorbic acid and trolox.

Keywords

  • Organic Chemistry
  • Geranium lasiopus
  • Geraniaceae
  • flavonoids
  • tannin
  • antioxidant activity

Other

Published
  • ISSN: 1478-6419
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

+46 46 222 82 13

+46 70 530 66 49

B127

Sölvegatan 27, Lund

39

Professor

Centre for Analysis and Synthesis

+46 46 222 82 13

1