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Hormonemate, a new cytotoxic and apoptosis-inducing compound from the endophytic fungus Hormonema dematioides. I. Identification of the producing strain, and isolation and biological properties of hormonemate

Author:
  • P Filip
  • RWS Weber
  • Olov Sterner
  • T Anke
Publishing year: 2003
Language: English
Pages: 547-552
Publication/Series: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
Volume: 58
Issue: 7-8
Document type: Journal article
Publisher: Verlag der Zeitschrift für Naturforschung

Abstract english

In a search for new fungal compounds inducing apoptosis of the colon cancer derived cell line COLO-320, hormonemate (1) was purified from fermentations of an endophytic fungus isolated from living needles of a Pinus species. The producing strain was identified as Hormonema dematioides by microscopy and ITS rDNA sequence analysis. The structure of hormonemate was determined by spectroscopic methods. The compound exhibited cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 as well as five other human cell lines (HL-60, JURKAT, HEP-G2, MCF-7, HeLa S3). It also induced apoptosis in COLO-320 cells as detected by a caspase-activity assay and morphological changes, and it triggered morphological and physiological differentiation of HL-60 cells into granulocytes, which subsequently died by apoptosis.

Keywords

  • Organic Chemistry
  • hormonemate
  • endophyte
  • Hormonema dematioides

Other

Published
  • ISSN: 0939-5075
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

Dean

Faculty of Science

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+46 70 530 66 49

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Professor

Centre for Analysis and Synthesis

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