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Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)

Author:
  • Maria Andersson
  • Ola Bergendorff
  • Rudong Shan
  • Peter Zygmunt
  • Olov Sterner
Publishing year: 1997
Language: English
Pages: 251-254
Publication/Series: Planta Medica
Volume: 63
Issue: 3
Document type: Journal article
Publisher: Georg Thieme Verlag

Abstract english

All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.

Keywords

  • Medicinal Chemistry
  • Dermatology and Venereal Diseases
  • Pharmacology and Toxicology
  • Scented myrrh
  • Commiphora guidotti
  • Burseraceae
  • sesquiterpenes
  • T-cadinol
  • smooth muscle relaxant

Other

Published
  • ISSN: 0032-0943
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

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