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The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus

Author:
  • V Mierau
  • Veronica de la Parra
  • Olov Sterner
  • T Anke
Publishing year: 2006
Language: English
Pages: 53-56
Publication/Series: Journal of Antibiotics
Volume: 59
Issue: 1
Document type: Journal article
Publisher: Japan Antibiotics Research Association

Abstract english

In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).

Keywords

  • Organic Chemistry
  • activities
  • cytotoxic
  • Dasyscyphus niveus
  • niveulone
  • dasyscyphins
  • A similar to C

Other

Published
  • ISSN: 0021-8820
Olov Sterner
E-mail: olov [dot] sterner [at] science [dot] lu [dot] se

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