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Kristian Pietras

Kristian Pietras

Research team manager

Kristian Pietras

Deconstructing tumor heterogeneity : The stromal perspective

Author

  • Renee E. Vickman
  • Douglas V. Faget
  • Philip Beachy
  • David Beebe
  • Neil A. Bhowmick
  • Edna Cukierman
  • Wu Min Deng
  • James G. Granneman
  • Jeffrey Hildesheim
  • Raghu Kalluri
  • Ken S. Lau
  • Ernst Lengyel
  • Joakim Lundeberg
  • Jorge Moscat
  • Peter S. Nelson
  • Kristian Pietras
  • Katerina Politi
  • Ellen Puré
  • Ruth Scherz-Shouval
  • Mara H. Sherman
  • David Tuveson
  • Ashani T. Weeraratna
  • Richard M. White
  • Melissa H. Wong
  • Elisa C. Woodhouse
  • Ying Zheng
  • Simon W. Hayward
  • Sheila A. Stewart
Show all

Summary, in English

Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field.

Department/s

  • LUCC: Lund University Cancer Centre
  • Experimental oncology

Publishing year

2020

Language

English

Pages

3621-3632

Publication/Series

Oncotarget

Volume

11

Issue

40

Document type

Journal article review

Publisher

Impact Journals

Topic

  • Cancer and Oncology

Keywords

  • Cellular plasticity
  • Extracellular matrix
  • Stromal heterogeneity
  • Therapy resistance
  • Tumor microenvironment

Status

Published

Research group

  • Experimental oncology

ISBN/ISSN/Other

  • ISSN: 1949-2553