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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Chromosomal translocations and leukaemia : a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis

Author

  • T H Rabbitts
  • H Axelson
  • A Forster
  • G Grutz
  • I Lavenir
  • R Larson
  • H Osada
  • V Valge-Archer
  • I Wadman
  • A Warren

Summary, in English

The LMO2 gene associated with T cell acute leukaemia has been used as an example of a gene activated by association with the T cell receptor genes after chromosomal translocations. The gene is shown to encode a LIM protein which is involved in protein interactions and during normal haematopoiesis is necessary for erythroid development. LMO2 has been shown to cause tumours when aberrantly expressed and to be able to heterodimerise with TAL1 to facilitate tumour development.

Department/s

  • Division of Translational Cancer Research

Publishing year

1997-04

Language

English

Pages

2-271

Publication/Series

Leukemia

Volume

11

Issue

Suppl 3

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Hematology
  • Medical Genetics

Keywords

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Chromosomes, Human, Pair 11
  • DNA-Binding Proteins
  • Erythropoiesis
  • Hematopoiesis
  • Humans
  • LIM Domain Proteins
  • Leukemia-Lymphoma, Adult T-Cell
  • Metalloproteins
  • Mice
  • Mice, Transgenic
  • Proto-Oncogene Proteins
  • Proto-Oncogenes
  • Transcription, Genetic
  • Translocation, Genetic

Status

Published

ISBN/ISSN/Other

  • ISSN: 0887-6924