The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Transcriptional deregulation of myc in IgH/myc 6;7 translocation carrying rat immunocytomas


  • H Axelson
  • W S Pear
  • C K Panda
  • H Bazin
  • G Klein
  • J Sümegi

Summary, in English

We have previously shown that the reciprocal translocation t(6;7) associated with the spontaneous immunocytoma of the Louvain rat (RIC) leads to the juxtaposition of myc to the IgH cluster. In 10 of 14 tumors investigated the breakpoints on the myc carrying chromosome were clustered in a 1.5 kb region 5' of the intact gene, proximal to the myc promoters. In this paper we describe the effect of the translocation on myc transcription in the RIC system. Run-on analysis showed transcriptional attenuation in the normal rat myc gene, similar to the situation in mice and humans. The attenuation was almost completely abrogated in the three immunocytomas studied. Sequence analysis of two tumors failed to reveal any structural changes within exon 1, as found by others in Burkitt's lymphoma. We also show that the transcriptional initiation of myc mRNA is changed in the RICs. In an established line of rat fibroblasts (Rat-2), the more distal myc promoter (P2) is the preferred site of initiation. In RIC, however, only 30% of transcripts were initiated from P2. We found that 40% of the transcripts were initiated from P1 and 30% from a novel promoter, designated P1a, located between P1 and P2.

Publishing year







Genes, Chromosomes and Cancer





Document type

Journal article


John Wiley & Sons Inc.


  • Medical Genetics


  • Animals
  • Base Sequence
  • Burkitt Lymphoma
  • DNA Mutational Analysis
  • DNA, Neoplasm
  • Gene Expression Regulation, Neoplastic
  • Genes, Immunoglobulin
  • Genes, myc
  • Humans
  • Immunoglobulin Heavy Chains
  • Lymphoma
  • Mice
  • Molecular Sequence Data
  • Plasmacytoma
  • Promoter Regions, Genetic
  • Rats
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Transcription, Genetic
  • Translocation, Genetic
  • Transplantation, Heterologous




  • ISSN: 1045-2257