
Håkan Axelson
Research team manager

Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice
Author
Summary, in English
Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.
Department/s
- Surgery
- Division of Translational Cancer Research
Publishing year
1992-06
Language
English
Pages
7-1241
Publication/Series
Oncogene
Volume
7
Issue
6
Document type
Journal article
Publisher
Nature Publishing Group
Keywords
- Abelson murine leukemia virus
- Animals
- Carcinogens
- DNA
- DNA, Neoplasm
- Enhancer Elements, Genetic
- Genes, Immunoglobulin
- Genes, myc
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Introns
- Mice
- Mice, Transgenic
- Plasmacytoma
- RNA
- RNA, Neoplasm
- Terpenes
- Translocation, Genetic
Status
Published
Research group
- Surgery
ISBN/ISSN/Other
- ISSN: 0950-9232