Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Association of erythroid transcription factors : complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1

  • H Osada
  • G Grutz
  • H Axelson
  • A Forster
  • T H Rabbitts
Publishing year: 1995-10-10
Language: English
Pages: 9-9585
Publication/Series: Proceedings of the National Academy of Sciences
Volume: 92
Issue: 21
Document type: Journal article
Publisher: National Acad Sciences

Abstract english

The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1. By using mammalian two-hybrid analysis, complexes involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix heterodimerization partner of TAL1, could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis, and the data suggest that variations in amounts of complexes involving RBTN2, TAL1, and GATA1 could be important for erythroid differentiation.


  • Hematology
  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins
  • Erythroid-Specific DNA-Binding Factors
  • Erythropoiesis
  • GATA1 Transcription Factor
  • Helix-Loop-Helix Motifs
  • Homeodomain Proteins
  • LIM Domain Proteins
  • Leukemia, Erythroblastic, Acute
  • Metalloproteins
  • Mice
  • Molecular Sequence Data
  • Protein Binding
  • Proto-Oncogene Proteins
  • Recombinant Proteins
  • TCF Transcription Factors
  • Transcription Factor 7-Like 1 Protein
  • Transcription Factors
  • Tumor Cells, Cultured
  • Zinc Fingers


  • ISSN: 0027-8424
Håkan Axelson
E-mail: hakan [dot] axelson [at] med [dot] lu [dot] se


Division of Translational Cancer Research

+46 46 222 64 34

MV 404 A31A2