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Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

  • Sophie Lehn
  • Nicholas P Tobin
  • Andrew H Sims
  • Olle Stål
  • Karin Jirström
  • Håkan Axelson
  • Göran Landberg
Publishing year: 2014
Language: English
Publication/Series: BMC Cancer
Volume: 14
Issue: 1
Document type: Journal article
Publisher: BioMed Central

Abstract english

Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.


  • Cancer and Oncology


  • Pathology, Malmö
  • Molecular Pathology, Malmö
  • ISSN: 1471-2407
Håkan Axelson
E-mail: hakan [dot] axelson [at] med [dot] lu [dot] se


Division of Translational Cancer Research

+46 46 222 64 34

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