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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Species diversity regarding the presence of proximal tubular progenitor cells of the kidney

Author

  • J Hansson
  • A E Ericsson
  • Håkan Axelson
  • Martin Johansson

Summary, in English

The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.

Department/s

  • Division of Translational Cancer Research
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Clinical pathology, Malmö

Publishing year

2016

Language

English

Pages

2567-2567

Publication/Series

European Journal of Histochemistry

Volume

60

Issue

1

Document type

Journal article

Publisher

Page Press

Topic

  • Urology and Nephrology

Status

Published

Research group

  • Clinical pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 2038-8306