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The Notch and TGF-beta Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell Carcinoma.

  • Jonas Sjölund
  • Anna-Karin Boström
  • David Lindgren
  • Sugata Manna
  • Aristidis Moustakas
  • Börje Ljungberg
  • Martin Johansson
  • Erik Fredlund
  • Håkan Axelson
Publishing year: 2011
Language: English
Publication/Series: PLoS ONE
Volume: 6
Issue: 8
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Despite recent progress, therapy for metastatic clear cell renal cell carcinoma (CCRCC) is still inadequate. Dysregulated Notch signaling in CCRCC contributes to tumor growth, but the full spectrum of downstream processes regulated by Notch in this tumor form is unknown.


  • Cancer and Oncology


  • ISSN: 1932-6203
Håkan Axelson
E-mail: hakan [dot] axelson [at] med [dot] lu [dot] se


Division of Translational Cancer Research

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