Håkan Axelson
Research team manager
The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma
Author
Summary, in English
The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains elusive. Using SILAC and quantitative mass spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma (NB) cells. Our results reveal cooperation between individual miR-17-92 miRNAs and implicate miR-17-92 in multiple hallmarks of cancer, including proliferation and cell adhesion. Most importantly, we show that miR-17-92 is a potent inhibitor of TGF-beta signaling. By functioning both upstream and downstream of pSMAD2, miR-17-92 activation triggers downregulation of multiple key effectors along the TGF-beta signaling cascade as well as direct inhibition of TGF-beta-responsive genes.
Department/s
- Department of Translational Medicine
- Division of Translational Cancer Research
- Kidney cancer research group
Publishing year
2010
Language
English
Pages
762-773
Publication/Series
Molecular Cell
Volume
40
Issue
5
Document type
Journal article
Publisher
Cell Press
Topic
- Cancer and Oncology
Status
Published
Research group
- Kidney cancer research group
ISBN/ISSN/Other
- ISSN: 1097-4164