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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

Author

  • J Vandesompele
  • Anders Edsjö
  • K De Preter
  • Håkan Axelson
  • F Speleman
  • Sven Påhlman

Summary, in English

The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate positively in neuroblastoma. In addition, ID2 expression was proposed as a negative prognostic parameter. As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated. We found no correlation between MYCN and ID2 expression in neuroblastoma cell lines or tumor specimens. However, we did find a significant positive correlation between MYC and ID2 expressions in both MYCN-amplified and single-copy tumor specimens, and in MYCN single-copy cell lines. As previously reported, we also found an inverse correlation between MYC and MYCN expressions. Importantly, we could not confirm the reported prognostic power of ID2-expression in neuroblastoma. These data, obtained in two independent laboratories, challenge the previously proposed ID2-MYCN relation.

Department/s

  • Department of Translational Medicine

Publishing year

2003

Language

English

Pages

456-460

Publication/Series

Oncogene

Volume

22

Issue

3

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology

Keywords

  • prognosis
  • neuroblastoma
  • MYCN
  • ID2
  • MYC

Status

Published

ISBN/ISSN/Other

  • ISSN: 1476-5594