
Håkan Axelson
Research team manager

Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc
Author
Summary, in English
The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.
Department/s
- Division of Translational Cancer Research
Publishing year
1994-02-01
Language
English
Pages
21-418
Publication/Series
International Journal of Cancer
Volume
56
Issue
3
Document type
Journal article
Publisher
John Wiley & Sons Inc.
Keywords
- Animals
- Cell Line
- Chromosome Mapping
- DNA, Neoplasm
- Genes, Immunoglobulin
- Genes, myc
- Immunoglobulin Heavy Chains
- Leukemia, Lymphocytic, Chronic, B-Cell
- Multigene Family
- Rats
- Rats, Inbred Strains
- Restriction Mapping
- Translocation, Genetic
- Tumor Cells, Cultured
Status
Published
ISBN/ISSN/Other
- ISSN: 0020-7136