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Håkan Axelson

Håkan Axelson

Research team manager

Håkan Axelson

Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc

Author

  • H Axelson
  • C K Panda
  • G Klein

Summary, in English

The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.

Department/s

  • Division of Translational Cancer Research

Publishing year

1994-02-01

Language

English

Pages

21-418

Publication/Series

International Journal of Cancer

Volume

56

Issue

3

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Keywords

  • Animals
  • Cell Line
  • Chromosome Mapping
  • DNA, Neoplasm
  • Genes, Immunoglobulin
  • Genes, myc
  • Immunoglobulin Heavy Chains
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Multigene Family
  • Rats
  • Rats, Inbred Strains
  • Restriction Mapping
  • Translocation, Genetic
  • Tumor Cells, Cultured

Status

Published

ISBN/ISSN/Other

  • ISSN: 0020-7136