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Absolute quantification of cerebral blood flow in normal volunteers: Correlation between Xe-133SPECT and dynamic susceptibility contrast MRI

  • Linda Knutsson
  • Siv Börjesson
  • Elna-Marie Larsson
  • Jarl Risberg
  • Lars Gustafson
  • Ulla Passant
  • Freddy Ståhlberg
  • Ronnie Wirestam
Publishing year: 2007
Language: English
Pages: 913-920
Publication/Series: Journal of Magnetic Resonance Imaging
Volume: 26
Issue: 4
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

Purpose: To compare, absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT. Materials and Methods: CBF was measured in 20 healthy volunteers using DSC-MRI at 3T and Xe-133 SPECT. DSC- MRI was accomplished by gradient-echo EPI and CBF was calculated using a time-shift-insenisitive deconvolution algorithm and regional arterial input functions (AIFs). To improve the reproducibility of AIF registration the time integral was rescaled by use, of a venous output function. In the Xe-133 SPECT experiment, Xe-133 gas was inhaled over 8 minutes and CBF was calculated using a biexponential analysis. Results: The average whole-brain CBF estimates obtained by DSC-MRI and Xe- 133 SPECT were 85 +/- 23 mL/(min 100 g) and 40 +/- 8 mL/(min 100 g), respectively (mean +/- SD, n = 20). The linear CBF relationship between the two modalities showed a correlation coefficient of r = 0.76 and was described by the equation CBF(MRI) = 2.4 CBF(Xe) - 7.9 (CBF in units of mL/(min 100 g)). Conclusion: A reasonable positive linear correlation between MRI-based and SPECT-based CBF estimates was observed after AIF time-integral correction. The use of DSC-MRI typically results in overestimated absolute perfusion estimates and the present study indicates that this trend is further enhanced by the use of high magnetic field strength (3T).


  • Radiology, Nuclear Medicine and Medical Imaging
  • magnetic
  • cerebral blood flow
  • dynamic susceptibility contrast
  • resonance imaging
  • perfusion
  • Xe-133SPECT


  • ISSN: 1522-2586
Freddy Ståhlberg
E-mail: freddy [dot] stahlberg [at] med [dot] lu [dot] se


Medical Radiation Physics, Lund

+46 46 17 31 19

+46 70 688 31 19



Diagnostic Radiology, (Lund)

+46 46 17 70 30


Project manager

MR Physics