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Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

  • Ronnie Wirestam
  • Emelie Lind
  • Danielle van Westen
  • Karin Markenroth Bloch
  • Freddy Ståhlberg
  • Linda Knutsson
Publishing year: 2010
Language: English
Pages: 375-379
Publication/Series: Clinical Physiology and Functional Imaging
Volume: 30
Issue: 5
Document type: Journal article
Publisher: Wiley Online Library

Abstract english

Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).


  • Physiology


  • ISSN: 1475-0961
Freddy Ståhlberg
E-mail: freddy [dot] stahlberg [at] med [dot] lu [dot] se


Medical Radiation Physics, Lund

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Diagnostic Radiology, (Lund)

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MR Physics