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Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities.

  • Linda Knutsson
  • Freddy Ståhlberg
  • Ronnie Wirestam
Publishing year: 2010
Language: English
Pages: 1-21
Publication/Series: Magma (New York, N.Y.)
Volume: 23
Document type: Journal article
Publisher: Springer

Abstract english

Absolute quantification of cerebral blood flow, cerebral blood volume and mean transit time is desirable in the determination of tissue viability thresholds and tissue at risk in acute ischaemic stroke, as well as in cases where a global reduction in cerebral blood flow is expected, for example, in patients with dementia or depressive disorders. Absolute values are also useful when comparing sequential examinations of tissue perfusion parameters, for example, in the monitoring and follow-up of various kinds of therapy. Regardless of the method employed, a number of assumptions and approximations must be made to obtain absolute measures of perfusion. Furthermore, the different stages of data acquisition and processing are associated with various degrees of uncertainty. In this review, the problems of particular relevance to absolute quantification of cerebral perfusion parameters using dynamic susceptibility contrast magnetic resonance imaging are discussed, and possible solutions are outlined.


  • Radiology, Nuclear Medicine and Medical Imaging


  • ISSN: 1352-8661
Freddy Ståhlberg
E-mail: freddy [dot] stahlberg [at] med [dot] lu [dot] se


Medical Radiation Physics, Lund

+46 46 17 31 19

+46 70 688 31 19



Diagnostic Radiology, (Lund)

+46 46 17 70 30


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MR Physics