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Effects of blood ΔR(2)* non-linearity on absolute perfusion quantification using DSC-MRI: Comparison with Xe-133 SPECT.

  • Linda Knutsson
  • Freddy Ståhlberg
  • Ronnie Wirestam
  • Matthias J van Osch
Publishing year: 2013
Language: English
Pages: 651-655
Publication/Series: Magnetic Resonance Imaging
Volume: 31
Issue: 5
Document type: Journal article
Publisher: Elsevier

Abstract english

PURPOSE: To evaluate whether a non-linear blood ΔR(2)*-versus-concentration relationship improves quantitative cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast (DSC) MRI in a comparison with Xe-133 SPECT CBF in healthy volunteers. MATERIAL AND METHODS: Linear as well as non-linear relationships between ΔR(2)* and contrast agent concentration in blood were applied to the arterial input function (AIF) and the venous output function (VOF) from DSC-MRI. To reduce partial volume effects in the AIF, the arterial time integral was rescaled using a corrected VOF scheme. RESULTS: Under the assumption of proportionality between the two modalities, the relationship CBF(MRI)=0.58CBF(SPECT) (r=0.64) was observed using the linear relationship and CBF(MRI)=0.51CBF(SPECT) (r=0.71) using the non-linear relationship. DISCUSSION: A smaller ratio of the VOF time integral to the AIF time integral and a somewhat better correlation between global DSC-MRI and Xe-133 SPECT CBF estimates were observed using the non-linear relationship. The results did not, however, confirm the superiority of one model over the other, potentially because realistic AIF signal data may well originate from a combination of blood and surrounding tissue.


  • Radiology, Nuclear Medicine and Medical Imaging


  • ISSN: 1873-5894
Freddy Ståhlberg
E-mail: freddy [dot] stahlberg [at] med [dot] lu [dot] se


Medical Radiation Physics, Lund

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Diagnostic Radiology, (Lund)

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MR Physics