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Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging

  • C Nilsson
  • Freddy Ståhlberg
  • C Thomsen
  • O Henriksen
  • M Herning
  • Christer Owman
Publishing year: 1992
Language: English
Pages: 20-24
Publication/Series: American Journal of Physiology
Volume: 262
Issue: 1
Document type: Journal article
Publisher: American Pysiological Society

Abstract english

Recent advances in magnetic resonance imaging have made it possible to visualize and quantify flow of cerebrospinal fluid (CSF) in the brain. The net flow of CSF through the cerebral aqueduct was used to measure CSF production in six normal volunteers at different times during a 24-h period. CSF production varied greatly both intra- and interindividually. The average CSF production in each time interval showed a clear tendency to circadian variation, with a minimum production 30% of maximum values (12 +/- 7 ml/h) approximately 1800 h and a nightly peak production approximately 0200 h of 42 +/- 2 ml/h. The total CSF production during the whole 24-h period, calculated as an average of all measurements, was 650 ml for the whole group and 630 ml for repeated measurements in each time interval in one of the volunteers.


  • Radiology, Nuclear Medicine and Medical Imaging
  • Pharmacology and Toxicology


  • Drug Target Discovery
  • ISSN: 0002-9513
Freddy Ståhlberg
E-mail: freddy [dot] stahlberg [at] med [dot] lu [dot] se


Medical Radiation Physics, Lund

+46 46 17 31 19

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MR Physics