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Regional cerebral blood flow distributions in normal volunteers: dynamic susceptibility contrast MRI compared with 99mTc-HMPAO SPECT

  • Ronnie Wirestam
  • Erik Ryding
  • Arne Lindgren
  • Bo Geijer
  • Leif Ostergaard
  • Linda Knutsson
  • Stig Holtås
  • Freddy Ståhlberg
Publishing year: 2000
Language: English
Pages: 526-530
Publication/Series: Journal of Computer Assisted Tomography
Volume: 24
Issue: 4
Document type: Journal article
Publisher: Raven Press

Abstract english

PURPOSE: Relative regional cerebral blood flow (rCBF) at rest was measured in 44 volunteers using both dynamic susceptibility contrast (DSC) MRI and (99m)Tc-HMPAO SPECT on the same day. METHOD: In MRI, a Gd-DTPA-BMA contrast agent bolus (0.3 mmol/kg body wt) was monitored with a simultaneous dual FLASH pulse sequence (time resolution 1.5 s). MRI-based rCBF images were calculated by singular value decomposition-based deconvolution of the measured tissue concentration-time curve with an arterial input function from a small artery within the imaging slice. In the SPECT investigation, 900 MBq of (99m)Tc-HMPAO was injected intravenously. Relative rCBF in gray matter in the thalamus and in frontal white matter was determined. RESULTS: The ratio of relative rCBF in gray matter to relative rCBF in white matter was 2.21 +/- 0.57 using MRI and 2.24 +/- 0.54 using SPECT (mean +/- SD). CONCLUSION: Relative rCBF maps from DSC MRI and (99m)Tc-HMPAO SPECT showed good agreement, and the MRI-based rCBF ratio correlated with the corresponding SPECT-based ratio (r = 0.79, p < 0.0000006).


  • Neurology
  • Radiology, Nuclear Medicine and Medical Imaging


  • ISSN: 1532-3145
Freddy Ståhlberg
E-mail: freddy [dot] stahlberg [at] med [dot] lu [dot] se


Medical Radiation Physics, Lund

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