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A linear mixed perfusion model for tissue partial volume correction of perfusion estimates in dynamic susceptibility contrast MRI: : Impact on absolute quantification, repeatability, and agreement with pseudo-continuous arterial spin labeling

  • André Ahlgren
  • Ronnie Wirestam
  • Emelie Lind
  • Freddy Ståhlberg
  • Linda Knutsson
Publishing year: 2017
Language: English
Pages: 2203-2214
Publication/Series: Magnetic Resonance in Medicine
Volume: 77
Issue: 6
Document type: Journal article
Publisher: Wiley Online Library

Abstract english

PURPOSE: The partial volume effect (PVE) is an important source of bias in brain perfusion measurements. The impact of tissue PVEs in perfusion measurements with dynamic susceptibility contrast MRI (DSC-MRI) has not yet been well established. The purpose of this study was to suggest a partial volume correction (PVC) approach for DSC-MRI and to study how PVC affects DSC-MRI perfusion results.

METHODS: A linear mixed perfusion model for DSC-MRI was derived and evaluated by way of simulations. Twenty healthy volunteers were scanned twice, including DSC-MRI, arterial spin labeling (ASL), and partial volume measurements. Two different algorithms for PVC were employed and assessed.

RESULTS: Simulations showed that the derived model had a tendency to overestimate perfusion values in voxels with high fractions of cerebrospinal fluid. PVC reduced the tissue volume dependence of DSC-MRI perfusion values from 44.4% to 4.2% in gray matter and from 55.3% to 14.2% in white matter. One PVC method significantly improved the voxel-wise repeatability, but PVC did not improve the spatial agreement between DSC-MRI and ASL perfusion maps.

CONCLUSION: Significant PVEs were found for DSC-MRI perfusion estimates, and PVC successfully reduced those effects. The findings suggest that PVC might be an important consideration for DSC-MRI applications. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.


  • Radiology, Nuclear Medicine and Medical Imaging


  • ISSN: 1522-2594
Freddy Ståhlberg
E-mail: freddy [dot] stahlberg [at] med [dot] lu [dot] se


Medical Radiation Physics, Lund

+46 46 17 31 19

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Diagnostic Radiology, (Lund)

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MR Physics