The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer
Summary, in English
Current prognostic molecular markers for epithelial ovarian cancer (EOC) are
insufficient. The aim of the current study was to investigate the role of Sox11 in EOC
Using an in silico transcriptomic screen Sox11 was identified as a potential EOC
biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC)
in 76 EOC cases, which were analyzed using automated algorithms to develop a
quantitative scoring model.
Sox11 mRNA expression was up-regulated in EOC compared to normal tissues.
Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in
40% of tumours, who had an improved recurrence free survival (RFS) (p= 0.002).
Multivariate analysis confirmed Sox11 was an independent predictor of improved RFS
after controlling for stage and grade.
These data suggest that Sox11 is a new prognostic marker in EOC. Loss of SOX 11 is
associated with a decreased RFS and a more aggressive phenotype.
- Department of Immunotechnology
- Therapeutic pathology
European Journal of Cancer
- Immunology in the medical area
- ISSN: 1879-0852