
Carl Borrebaeck
Professor

Nanosphere induced gene expression in human dendritic cells
Author
Summary, in English
The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.
Department/s
- Department of Immunotechnology
Publishing year
2005
Language
English
Pages
2168-2173
Publication/Series
Nano Letters
Volume
5
Issue
11
Document type
Journal article
Publisher
The American Chemical Society (ACS)
Topic
- Nano Technology
Status
Published
ISBN/ISSN/Other
- ISSN: 1530-6992