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Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival

Author:
  • Sara Ek
  • Erik Bjorck
  • Carl-Magnus Högerkorp
  • Magnus Nordenskjold
  • Anna Porwit-Macdonald
  • Carl Borrebaeck
Publishing year: 2006
Language: English
Pages: 2092-2097
Publication/Series: International Journal of Cancer
Volume: 118
Issue: 8
Document type: Journal article
Publisher: John Wiley & Sons

Abstract english

We have analyzed mantle cell lymphomas (MCLs), using high-density DNA microarrays, and confirmed the expression of differentially regulated antigens, using flow cytometry and immunohistochemistry. The results show that MCLs acquire expression of molecules that normally are involved in interaction with other immune cells and, thus, might affect the ability of the tumor to survive. The MCL signature is represented by the overexpression of the chemokine CCL4 (MIP-1), implicated in the recruitment of regulatory T cells, as well as CCL5 and 4-1BB-L. The latter molecules are normally involved in chemotaxis of T cells and B cell activation, respectively. Signaling through 4-1BB-L allows B cells to proliferate and the expression of its ligand, by the intra-tumoral mesh of follicular dendritic cells (FDC), could thus serve as a paracrine loop facilitating growth and survival of MCL cells.

Keywords

  • Cancer and Oncology

Other

Published
  • ISSN: 0020-7136
Carl Borrebaeck
E-mail: carl [dot] borrebaeck [at] immun [dot] lth [dot] se

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Department of Immunotechnology

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