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Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays

Author:
  • Peter Ellmark
  • Carl-Magnus Högerkorp
  • Sara Ek
  • Larissa Beelov
  • Mattias Berglund
  • Richard Rosenquist
  • Richard Christopherson
  • Carl Borrebaeck
Publishing year: 2008
Language: English
Pages: 98-106
Publication/Series: Cancer Letters
Volume: 265
Document type: Journal article
Publisher: Elsevier

Abstract english

Antibody microarrays enable extensive protein expression profiling, and provide a valuable complement to DNA microarray-based gene expression profiling. In this study, we used DotScan™ antibody microarrays that contain antibodies against 82 different cell surface antigens, to determine phenotypic protein expression profiles for human B cell sub-populations. We then demonstrated that the B cell protein profile can be used to delineate the relationship between normal B cells and malignant counterparts. Principle component analysis showed that the lymphomas did not cluster with the normal memory B cells or germinal centre B cells, but they did cluster with germinal centre founder cells and naïve B cells.

Keywords

  • Cancer and Oncology

Other

Published
  • Carl Borrebaeck-lup-obsolete
  • ISSN: 1872-7980
Carl Borrebaeck
E-mail: carl [dot] borrebaeck [at] immun [dot] lth [dot] se

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Department of Immunotechnology

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