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Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency.

Author:
  • Ann-Sofie Albrekt
  • Henrik Johansson
  • Anna Börjesson
  • Carl Borrebaeck
  • Malin Lindstedt
Publishing year: 2014
Language: English
Publication/Series: BMC Pharmacology
Volume: 15
Issue: 1
Document type: Journal article
Publisher: BioMed Central

Abstract english

Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly prioritized. To date, proposed in vitro assays are mainly based on single biomarkers, which so far have not been able to classify and stratify chemicals into subgroups, related to risk or potency.

Keywords

  • Immunology in the medical area

Other

Published
  • ISSN: 2050-6511
Carl B
Carl Borrebaeck
E-mail: carl [dot] borrebaeck [at] immun [dot] lth [dot] se

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Department of Immunotechnology

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