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Nanosphere induced gene expression in human dendritic cells

Author:
  • M Matsusaki
  • Kristina Larsson
  • T Akagi
  • Malin Lindstedt
  • M Akashi
  • Carl Borrebaeck
Publishing year: 2005
Language: English
Pages: 2168-2173
Publication/Series: Nano Letters
Volume: 5
Issue: 11
Document type: Journal article
Publisher: The American Chemical Society

Abstract english

The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.

Keywords

  • Nano Technology

Other

Published
  • ISSN: 1530-6992
Carl B
Carl Borrebaeck
E-mail: carl [dot] borrebaeck [at] immun [dot] lth [dot] se

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Department of Immunotechnology

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