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Carl B

Carl Borrebaeck

Professor

Carl B

Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays

Author

  • Peter Ellmark
  • Carl-Magnus Högerkorp
  • Sara Ek
  • Larissa Beelov
  • Mattias Berglund
  • Richard Rosenquist
  • Richard Christopherson
  • Carl Borrebaeck

Summary, in English

Antibody microarrays enable extensive protein expression profiling, and provide a valuable complement to DNA microarray-based gene expression profiling. In this study, we used DotScan™ antibody microarrays that contain antibodies against 82 different cell surface antigens, to determine phenotypic protein expression profiles for human B cell sub-populations. We then demonstrated that the B cell protein profile can be used to delineate the relationship between normal B cells and malignant counterparts. Principle component analysis showed that the lymphomas did not cluster with the normal memory B cells or germinal centre B cells, but they did cluster with germinal centre founder cells and naïve B cells.

Department/s

  • Department of Immunotechnology

Publishing year

2008

Language

English

Pages

98-106

Publication/Series

Cancer Letters

Volume

265

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1872-7980