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Analiza rokowniczego znaczenia mutacji genu TP53 u chorych na niedrobnokomorkowego raka pluca

Analysis of prognostic value of TP53 gene mutations in non-small cell lung cancer
Author:
  • Amelia Szymanowska
  • Ewa Jassem
  • Rafal Dziadziuszko
  • Marcin Skrzypski
  • Grazyna Kobierska-Gulida
  • Karolina Holm
  • Åke Borg
  • Witold Rzyman
  • Janusz Limon
  • Jacek Jassem
Publishing year: 2005
Language: Polish
Pages: 264-269
Publication/Series: Pneumonologia i Alergologia Polska
Volume: 73
Issue: 3
Document type: Journal article
Publisher: Wydawnictwo Viamedica SPZOO

Abstract english

The aim of this study was to assess the frequency and prognostic value of TP53 gene somatic mutations in non-small cell lung cancer. The study group included 240 NSCLC patients who underwent pulmonary resection at the Department of Thoracic Surgery, Medical University of Gdansk. Tumour samples were evaluated for the presence of TP53 gene mutations in exons 5-8. In 157 cases SSCP method was used as a screening followed by sequencing of positive samples. In the remaining 83 patients mutations were analysed by direct sequencing. A total of 76 mutations (32%) were found, of those a missense type was dominant (67%), followed by silent and null type mutations (14% and 10%, respectively). There was no correlation between mutations and clinical characteristics, including age, sex, histological subtype, differentiation, tumour size, lymph node metastases, pTNM stage and smoking status. A multivariate Cox analysis demonstrated that tumour differentiation and pTNM stage were independent prognostic factors, whereas TP53 gene mutations were not. The results of this study indicate that TP53 gene mutations in NSCLC patients are not correlated with clinical characteristics and have no impact on survival.

Keywords

  • Cancer and Oncology

Other

Published
  • ISSN: 0867-7077
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

90

Professor

Oncology and Pathology, MV

MV 404 C21C2

90