Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.

Summary, in English

Although familial susceptibility to glioma is known, the genetic basis for this susceptibility remains unidentified in the majority of glioma-specific families. An alternative approach to identifying such genes is to examine cancer pedigrees, which include glioma as one of several cancer phenotypes, to determine whether common chromosomal modifications might account for the familial aggregation of glioma and other cancers.

• Author: Ulrika Andersson; Carl Wibom; Kristina Cederquist; Steina Aradottir; Åke Borg; Georgina N Armstrong; Sanjay Shete; Ching C Lau; Matthew N Bainbridge; Elizabeth B Claus; Jill Barnholtz-Sloan; Rose Lai; Dora Il'yasova; Richard S Houlston; Joellen Schildkraut; Jonine L Bernstein; Sara H Olson; Robert B Jenkins; Daniel H Lachance; Margaret Wrensch; Faith G Davis; Ryan Merrell; Christoffer Johansen; Siegal Sadetzki; Melissa L Bondy; Beatrice S Melin
• Department/s: Breastcancer-genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2014
• Language: English
• Pages: 1333-1340
• Publication/Series: Neuro-Oncology
• Volume: 16
• Issue: 10
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24723567?dopt=Abstract; http://dx.doi.org/10.1093/neuonc/nou052
• Document type: Journal article
• Publisher: Oxford University Press
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1523-5866