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The molecular signature of MDS stem cells supports a stem-cell origin of 5q - myelodysplastic syndromes

Author:
  • Lars Nilsson
  • Patrik Edén
  • Eleonor Olsson
  • Robert Månsson
  • Ingbritt Åstrand-Grundström
  • Bodil Strömbeck
  • Kim Theilgaard-Moench
  • Kristina Anderson
  • Robert Hast
  • Eva Hellström
  • Jan Samuelsson
  • Goesta Bergh
  • Claus Nerlov
  • Bertil Johansson
  • Mikael Sigvardsson
  • Åke Borg
  • Sten Eirik W Jacobsen
Publishing year: 2007
Language: English
Pages: 3005-3014
Publication/Series: Blood
Volume: 110
Issue: 8
Document type: Journal article
Publisher: American Society of Hematology

Abstract english

Global gene expression profiling of highly purified 5q-deleted CD34(+)CD38(-)Thy1(+) cells in 5q(-) myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34(+)CD38(-)Thy1(+) hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cells. Expression of BMI1, encoding a critical regulator of self-renewal, was up-regulated in 5q- stem cells. Whereas multiple previous MDS genetic screens failed to identify altered expression of the gene encoding the myeloid transcription factor CEBPA, stage-specific and extensive down-regulation of CEBPA was specifically observed in MDS progenitors. These studies establish the importance of molecular characterization of distinct stages of cancer stem and progenitor cells to enhance the resolution of stage-specific dysregulated gene expression.

Keywords

  • Hematology

Other

Published
  • ISSN: 1528-0020
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

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Professor

Oncology and Pathology, MV

MV 404 C21C2

90