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Identification of TP53 gene mutations in uterine corpus cancer with short follow-up

  • Anjila Koul
  • Åke Borg
  • Tanja Pejovic
  • Pär-Ola Bendahl
  • Thomas Högberg
  • Constantin Iosif
  • Dick Killander
Publishing year: 1997
Language: English
Pages: 295-302
Publication/Series: Gynecologic Oncology
Volume: 67
Issue: 3
Document type: Journal article
Publisher: Academic Press

Abstract english

The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.


  • Obstetrics, Gynecology and Reproductive Medicine
  • Cancer and Oncology
  • TP53
  • mutation
  • uterine corpus cancer
  • DNA ploidy


  • ISSN: 1095-6859
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2


Project manager

Familial Breast Cancer



Oncology and Pathology, MV

MV 404 C21C2