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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Identification of TP53 gene mutations in uterine corpus cancer with short follow-up

Author

  • Anjila Koul
  • Åke Borg
  • Tanja Pejovic
  • Pär-Ola Bendahl
  • Thomas Högberg
  • Constantin Iosif
  • Dick Killander

Summary, in English

The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.

Department/s

  • Breastcancer-genetics
  • Medical oncology
  • Obstetrics and Gynaecology (Lund)

Publishing year

1997

Language

English

Pages

295-302

Publication/Series

Gynecologic Oncology

Volume

67

Issue

3

Document type

Journal article

Publisher

Academic Press

Topic

  • Obstetrics, Gynecology and Reproductive Medicine
  • Cancer and Oncology

Keywords

  • TP53
  • mutation
  • uterine corpus cancer
  • DNA ploidy

Status

Published

ISBN/ISSN/Other

  • ISSN: 1095-6859