Åke Borg
Principal investigator
Identification of TP53 gene mutations in uterine corpus cancer with short follow-up
Author
Summary, in English
The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.
Department/s
- Breastcancer-genetics
- Medical oncology
- Obstetrics and Gynaecology (Lund)
Publishing year
1997
Language
English
Pages
295-302
Publication/Series
Gynecologic Oncology
Volume
67
Issue
3
Document type
Journal article
Publisher
Academic Press
Topic
- Obstetrics, Gynecology and Reproductive Medicine
- Cancer and Oncology
Keywords
- TP53
- mutation
- uterine corpus cancer
- DNA ploidy
Status
Published
ISBN/ISSN/Other
- ISSN: 1095-6859