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Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation

  • M Thomassen
  • TA Kruse
  • KE Olsen
  • Åke Borg
  • AM Gerdes
Publishing year: 2004
Language: English
Pages: 273-276
Publication/Series: Breast Cancer Research and Treatment
Volume: 87
Issue: 3
Document type: Journal article
Publisher: Springer

Abstract english

We have examined a family with a germline BRCA2 mutation in three cases of invasive breast cancer and one case of ductal carcinoma in situ ( DCIS). Loss of heterozygosity (LOH) has been demonstrated at the BRCA2 locus in all cases. This result may suggest that the germline mutation in BRCA2 is the initiating step of DCIS and support the theory that DCIS is a precursor of invasive breast carcinoma in hereditary breast cancer.


  • Cancer and Oncology
  • hereditary cancer
  • DCIS
  • BRCA2
  • breast cancer
  • LOH


  • ISSN: 1573-7217
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2


Project manager

Familial Breast Cancer



Oncology and Pathology, MV

MV 404 C21C2