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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation

Author

  • M Thomassen
  • TA Kruse
  • KE Olsen
  • Åke Borg
  • AM Gerdes

Summary, in English

We have examined a family with a germline BRCA2 mutation in three cases of invasive breast cancer and one case of ductal carcinoma in situ ( DCIS). Loss of heterozygosity (LOH) has been demonstrated at the BRCA2 locus in all cases. This result may suggest that the germline mutation in BRCA2 is the initiating step of DCIS and support the theory that DCIS is a precursor of invasive breast carcinoma in hereditary breast cancer.

Department/s

  • Breastcancer-genetics

Publishing year

2004

Language

English

Pages

273-276

Publication/Series

Breast Cancer Research and Treatment

Volume

87

Issue

3

Document type

Journal article

Publisher

Springer

Topic

  • Cancer and Oncology

Keywords

  • hereditary cancer
  • DCIS
  • BRCA2
  • breast cancer
  • LOH

Status

Published

ISBN/ISSN/Other

  • ISSN: 1573-7217