Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.

Author:
  • Paolo Peterlongo
  • Jenny Chang-Claude
  • Kirsten B Moysich
  • Anja Rudolph
  • Rita K Schmutzler
  • Jacques Simard
  • Penny Soucy
  • Rosalind A Eeles
  • Douglas F Easton
  • Ute Hamann
  • Stefan Wilkening
  • Bowang Chen
  • Matti A Rookus
  • Marjanka K Schmidt
  • Frederieke H van der Baan
  • Amanda B Spurdle
  • Logan C Walker
  • Felicity Lose
  • Ana-Teresa Maia
  • Marco Montagna
  • Laura Matricardi
  • Jan Lubinski
  • Anna Jakubowska
  • Encarna B Gomez-Garcia
  • Olufunmilayo I Olopade
  • Robert L Nussbaum
  • Katherine L Nathanson
  • Susan M Domchek
  • Timothy R Rebbeck
  • Banu K Arun
  • Beth Y Karlan
  • Sandra Orsulic
  • Jenny Lester
  • Wendy K Chung
  • Alex Miron
  • Melissa C Southey
  • David E Goldgar
  • Saundra S Buys
  • Ramunas Janavicius
  • Cecelia M Dorfling
  • Elizabeth J van Rensburg
  • Yuan Chun Ding
  • Susan L Neuhausen
  • Thomas V O Hansen
  • Anne-Marie Gerdes
  • Bent Ejlertsen
  • Lars Jønson
  • Ana Osorio
  • Cristina Martinez-Bouzas
  • Javier Benitez
  • Edye E Conway
  • Kathleen R Blazer
  • Jeffrey N Weitzel
  • Siranoush Manoukian
  • Bernard Peissel
  • Daniela Zaffaroni
  • Giulietta Scuvera
  • Monica Barile
  • Filomena Ficarazzi
  • Frederique Mariette
  • Stefano Fortuzzi
  • Alessandra Viel
  • Giuseppe Giannini
  • Laura Papi
  • Aline Martayan
  • Maria Grazia Tibiletti
  • Paolo Radice
  • Athanassios Vratimos
  • Florentia Fostira
  • Judy E Garber
  • Alan Donaldson
  • Carole Brewer
  • Claire Foo
  • D Gareth R Evans
  • Debra Frost
  • Diana Eccles
  • Angela Brady
  • Jackie Cook
  • Marc Tischkowitz
  • Julian Adlard
  • Julian Barwell
  • Lisa Walker
  • Louise Izatt
  • Lucy E Side
  • M John Kennedy
  • Mark T Rogers
  • Mary E Porteous
  • Patrick J Morrison
  • Radka Platte
  • Rosemarie Davidson
  • Shirley V Hodgson
  • Steve Ellis
  • Trevor Cole
  • Andrew K Godwin
  • Kathleen Claes
  • Tom Van Maerken
  • Alfons Meindl
  • Andrea Gehrig
  • Christian Sutter
  • Christoph Engel
  • Dieter Niederacher
  • Doris Steinemann
  • Hansjoerg Plendl
  • Karin Kast
  • Kerstin Rhiem
  • Nina Ditsch
  • Norbert Arnold
  • Raymonda Varon-Mateeva
  • Barbara Wappenschmidt
  • Shan Wang-Gohrke
  • Brigitte Bressac-de Paillerets
  • Bruno Buecher
  • Capucine Delnatte
  • Claude Houdayer
  • Dominique Stoppa-Lyonnet
  • Francesca Damiola
  • Isabelle Coupier
  • Laure Barjhoux
  • Laurence Venat-Bouvet
  • Lisa Golmard
  • Nadia Boutry-Kryza
  • Olga M Sinilnikova
  • Olivier Caron
  • Pascal Pujol
  • Sylvie Mazoyer
  • Muriel Belotti
  • Marion Piedmonte
  • Michael L Friedlander
  • Gustavo C Rodriguez
  • Larry J Copeland
  • Miguel de la Hoya
  • Pedro Perez Segura
  • Heli Nevanlinna
  • Kristiina Aittomäki
  • Theo A M van Os
  • Hanne E J Meijers-Heijboer
  • Annemarie H Van der Hout
  • Maaike P G Vreeswijk
  • Nicoline Hoogerbrugge
  • Margreet G E M Ausems
  • Helena C Van Doorn
  • J Margriet Collée
  • Edith Olah
  • Orland Díez
  • Ignacio Blanco
  • Conxi Lazaro
  • Joan Brunet
  • Lídia Feliubadaló
  • Cezary Cybulski
  • Jacek Gronwald
  • Katarzyna Durda
  • Katarzyna Jaworska-Bieniek
  • Grzegorz Sukiennicki
  • Adalgeir Arason
  • Jocelyne Chiquette
  • Manuel R Teixeira
  • Curtis Olswold
  • Fergus J Couch
  • Noralane M Lindor
  • Xianshu Wang
  • Csilla I Szabo
  • Kenneth Offit
  • Marina Corines
  • Lauren Jacobs
  • Mark Robson
  • Liying Zhang
  • Vijai Joseph
  • Andreas Berger
  • Christian F Singer
  • Christine Rappaport
  • Daphne Geschwantler Kaulich
  • Georg Pfeiler
  • Muy-Kheng M Tea
  • Catherine M Phelan
  • Mark H Greene
  • Phuong L Mai
  • Gad Rennert
  • Anna Marie Mulligan
  • Gord Glendon
  • Sandrine Tchatchou
  • Irene L Andrulis
  • Amanda Ewart Toland
  • Anders Bojesen
  • Inge Sokilde Pedersen
  • Mads Thomassen
  • Uffe Birk Jensen
  • Yael Laitman
  • Johanna Rantala
  • Anna von Wachenfeldt
  • Hans Ehrencrona
  • Marie Stenmark Askmalm
  • Åke Borg
  • Karoline B Kuchenbaecker
  • Lesley McGuffog
  • Daniel Barrowdale
  • Sue Healey
  • Andrew Lee
  • Paul D P Pharoah
  • Georgia Chenevix-Trench
  • Antonis C Antoniou
  • Eitan Friedman
Publishing year: 2015
Language: English
Pages: 308-316
Publication/Series: Cancer Epidemiology Biomarkers & Prevention
Volume: 24
Issue: 1
Document type: Journal article
Publisher: American Association for Cancer Research

Abstract english

Background: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and non-genetic modifying factors. In this study we evaluated the putative role of variants in many candidate modifier genes. Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n=3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach. Results: The observed p-values of association ranged between 0.005-1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments. Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies.

Keywords

  • Cancer and Oncology

Other

Published
  • ISSN: 1538-7755
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

90

Professor

Oncology and Pathology, MV

MV 404 C21C2

90