An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.

Summary, in English

Aberrant DNA methylation is frequently observed in breast cancer. However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized.

• Author: Karolina Holm; Johan Staaf; Martin Lauss; Mattias Aine; David Lindgren; Pär-Ola Bendahl; Johan Vallon-Christersson; Rosa Bjork Barkardottir; Mattias Höglund; Åke Borg; Göran B Jönsson; Markus Ringnér
• Department/s: Breastcancer-genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Division of Translational Cancer Research
• Publishing year: 2016
• Language: English
• Publication/Series: Breast Cancer Research
• Volume: 18
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26923702?dopt=Abstract; http://dx.doi.org/10.1186/s13058-016-0685-5
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1465-5411