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Low frequency of E-cadherin alterations in familial breast cancer

Author:
  • Sima Salahshor
  • Haixin Lei
  • Huagang Huo
  • Vessela N Kristensen
  • Niklas Loman
  • Sara Sjöberg-Margolin
  • Åke Borg
  • Anne-Lise Borresen-Dale
  • Igor Vorechovsky
  • Annika Lindblom
Publishing year: 2001
Language: English
Pages: 199-207
Publication/Series: Breast Cancer Research
Volume: 3
Issue: 3
Document type: Journal article
Publisher: BioMed Central

Abstract english

In order to explore the possible role of E-cadherin in familial cancer, 19 familial breast cancer patients, whose tumours demonstrated loss of heterozygosity (LOH) at the E-cadherin locus, were screened for germline mutations. No pathogenic germline alterations were detected in these individuals. However, a somatic mutation was found (49-2A-->C) in one of the tumours. This tumour showed a pattern of both ductal and lobular histology. Another 10 families with cases of breast, gastric and colon cancer were also screened for germline mutations, and no mutations were found. A missense mutation in exon 12 of E-cadherin (1774G-->A; Ala592Thr) was previously found in one family with diffuse gastric cancer, and colon and breast cancer. An allelic association study was performed to determine whether the Ala592Thr alteration predisposes to breast cancer. In total, we studied 484 familial breast cancer patients, 614 sporadic breast cancer patients and 497 control individuals. The frequencies of this alteration were similar in these groups. However, a correlation between the Ala592Thr alteration and ductal comedo-type tumour was seen. These results, together with previously reported studies, indicate that germline mutations and, more commonly, somatic mutations in E-cadherin may have an influence on the behaviour of the tumours, rather than predispose to breast cancer.

Keywords

  • Cancer and Oncology
  • breast cancer
  • ductal comedo-type
  • E-cadherin
  • familial
  • lobular

Other

Published
  • ISSN: 1465-5411
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

90

Professor

Oncology and Pathology, MV

MV 404 C21C2

90