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FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population

Author:
  • Johanna I. Kiiski
  • Anna Tervasmäki
  • Liisa M Pelttari
  • Sofia Khan
  • Tuomo Mantere
  • Katri Pylkäs
  • Arto Mannermaa
  • Maria Tengström
  • Anders Kvist
  • Åke Borg
  • Veli-Matti Kosma
  • Anne Kallioniemi
  • Johanna Schleutker
  • Ralf Bützow
  • Carl Blomqvist
  • Kristiina Aittomäki
  • Robert Winqvist
  • Heli Nevanlinna
Publishing year: 2017-07-12
Language: English
Pages: 1-10
Publication/Series: Breast Cancer Research and Treatment
Document type: Journal article
Publisher: Springer

Abstract english

Purpose: The FANCM c.5101C>T nonsense mutation was previously found to associate with breast cancer in the Finnish population, especially among triple-negative cases. Here, we studied the prevalence of three other FANCM variants: c.5791C>T, which has been reported to predispose to familial breast cancer, and the c.4025_4026delCT and c.5293dupA variants recently identified in Finnish cancer patients. Methods: We genotyped the FANCM c.5791C>T mutation in 4806 invasive breast cancer patients, including BRCA1/2 mutation negative familial cases and unselected cases, and in 2734 healthy population controls from four different geographical areas of Finland. The association of the mutation with breast cancer risk among patient subgroups was statistically evaluated. We further analyzed the combined risk associated with c.5101C>T and c.5791C>T mutations. We also genotyped 526 unselected ovarian cancer patients for the c.5791C>T mutation and 862 familial breast cancer patients for the c.4025_4026delCT and c.5293dupA variants. Results: The frequency of the FANCM c.5791C>T mutation was higher among breast cancer cases than in controls (OR 1.94, 95% CI 0.87–4.32, P = 0.11), with a statistically significant association with triple-negative breast cancer (OR 5.14, 95% CI 1.65–16.0, P = 0.005). The combined analysis for c.5101C>T and c.5791C>T carriers confirmed a strong association with breast cancer (OR 1.86, 95% CI 1.32–2.49, P = 0.0002), especially among the triple-negative patients (OR 3.08, 95% CI 1.77–5.35, P = 0.00007). For the other variants, only one additional c.4025_4026delCT carrier and no c.5293dupA carriers were observed. Conclusions: These results support the role of FANCM as a breast cancer susceptibility gene, particularly for triple-negative breast cancer.

Keywords

  • Cancer and Oncology
  • Breast cancer
  • DNA repair
  • Familial breast cancer
  • FANCM
  • Triple-negative breast cancer

Other

Epub
  • Familial Breast Cancer
  • ISSN: 0167-6806
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

90

Professor

Oncology and Pathology, MV

MV 404 C21C2

90