
Åke Borg
Principal investigator

The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs.
Author
Summary, in English
Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to guide sequence-specific cleavage and regulate gene expression similarly to miRNAs. We demonstrate that svRNAb downregulates CYP3A4, a key enzyme in drug metabolism. Our findings expand the repertoire of small regulatory RNAs and assign, for the first time, a function to vRNAs that may help explain the association between vault particles and drug resistance.
Department/s
- Breastcancer-genetics
- Clinical Virology, Malmö
- Cancer and non coding RNA
Publishing year
2009
Language
English
Pages
1268-1271
Publication/Series
Nature Cell Biology
Volume
11
Issue
10
Links
Document type
Journal article
Publisher
Nature Publishing Group
Topic
- Cancer and Oncology
- Microbiology in the medical area
Status
Published
Research group
- Clinical Virology, Malmö
- Cancer and non coding RNA
ISBN/ISSN/Other
- ISSN: 1465-7392