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Åke Borg

Åke Borg

Principal investigator

Åke Borg

The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs.

Author

  • Helena Persson
  • Anders Kvist
  • Johan Vallon-Christersson
  • Patrik Medstrand
  • Åke Borg
  • Carlos Rovira

Summary, in English

Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to guide sequence-specific cleavage and regulate gene expression similarly to miRNAs. We demonstrate that svRNAb downregulates CYP3A4, a key enzyme in drug metabolism. Our findings expand the repertoire of small regulatory RNAs and assign, for the first time, a function to vRNAs that may help explain the association between vault particles and drug resistance.

Department/s

  • Breastcancer-genetics
  • Clinical Virology, Malmö
  • Cancer and non coding RNA

Publishing year

2009

Language

English

Pages

1268-1271

Publication/Series

Nature Cell Biology

Volume

11

Issue

10

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology
  • Microbiology in the medical area

Status

Published

Research group

  • Clinical Virology, Malmö
  • Cancer and non coding RNA

ISBN/ISSN/Other

  • ISSN: 1465-7392