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Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding

Author:
  • Ekaterina Kuchinskaya
  • Mats Heyman
  • Ann Nordgren
  • Jacqueline Schoumans
  • Johan Staaf
  • Åke Borg
  • Stefan Söderhäll
  • Dan Grander
  • Magnus Nordenskjöld
  • Elisabeth Blennow
Publishing year: 2008
Language: English
Pages: 572-577
Publication/Series: British Journal of Haematology
Volume: 140
Issue: 5
Document type: Journal article
Publisher: Federation of European Neuroscience Societies and Blackwell Publishing Ltd

Abstract english

A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.

Keywords

  • Hematology
  • tiling-resolution array-comparative genomic hybridization
  • childhood acute lymphoblastic leukaemia
  • normal karyotype

Other

Published
  • ISSN: 0007-1048
Åke Borg
Åke Borg
E-mail: ake [dot] borg [at] med [dot] lu [dot] se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

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Project manager

Familial Breast Cancer

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Professor

Oncology and Pathology, MV

MV 404 C21C2

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