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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding

Author

  • Ekaterina Kuchinskaya
  • Mats Heyman
  • Ann Nordgren
  • Jacqueline Schoumans
  • Johan Staaf
  • Åke Borg
  • Stefan Söderhäll
  • Dan Grander
  • Magnus Nordenskjöld
  • Elisabeth Blennow

Summary, in English

A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.

Department/s

  • Breastcancer-genetics

Publishing year

2008

Language

English

Pages

572-577

Publication/Series

British Journal of Haematology

Volume

140

Issue

5

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Hematology

Keywords

  • tiling-resolution array-comparative genomic hybridization
  • childhood acute lymphoblastic leukaemia
  • normal karyotype

Status

Published

ISBN/ISSN/Other

  • ISSN: 0007-1048