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B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.

Author:
  • Ulrika Andreasson
  • Sara Ek
  • Hartmut Merz
  • Richard Rosenquist
  • Niels Andersen
  • Mats Jerkeman
  • Michael Dictor
  • Carl A K Borrebaeck
Publishing year: 2008
Language: English
Pages: 138-145
Publication/Series: Cancer Letters
Volume: 259
Issue: 2
Document type: Journal article
Publisher: Elsevier

Abstract english

To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.

Keywords

  • Cancer and Oncology

Other

Published
  • CREATE Health
  • ISSN: 1872-7980
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