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Threshold-free high-power methods for the ontological analysis of genome-wide gene expression studies

  • Björn Nilsson
  • Petra Johnels
  • Mikael Johansson
  • Sven Nelander
  • Thoas Fioretos
Publishing year: 2007
Language: English
Publication/Series: Genome Biology
Volume: 8
Issue: 5
Document type: Journal article
Publisher: BioMed Central

Abstract english

Ontological analysis facilitates microarray data interpretation. We describe new ontological analysis methods which, unlike existing approaches, are threshold-free and statistically powerful. We perform extensive evaluations and introduce a new concept, detection spectra, to characterize methods. We show that different ontological analysis methods exhibit distinct detection spectra, and that it is critical to account for this diversity. Our results argue strongly against the continued use of existing methods, and provide directions towards an enhanced approach.


  • Medical Genetics


  • ISSN: 1474-7596
Thoas Fioretos
E-mail: thoas.fioretos [at]

Principal investigator

Division of Clinical Genetics

+46 46 222 45 95

+46 70 334 33 67