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Thoas Fioretos

Thoas Fioretos

Research team manager

Thoas Fioretos

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Author

  • Henrik Lilljebjörn
  • Thoas Fioretos

Summary, in English

Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

Department/s

  • Division of Clinical Genetics
  • Translational Genomic and Functional Studies of Leukemia
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2017-09-21

Language

English

Pages

1395-1401

Publication/Series

Blood

Volume

130

Issue

12

Document type

Journal article review

Publisher

American Society of Hematology

Topic

  • Hematology
  • Cancer and Oncology

Status

Published

Research group

  • Translational Genomic and Functional Studies of Leukemia

ISBN/ISSN/Other

  • ISSN: 0006-4971