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Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

  • Thoas Fioretos
  • Sverre Heim
  • Stanislaw Garwicz
  • J Ludvigsson
  • Felix Mitelman
Publishing year: 1992
Language: English
Pages: 723-725
Publication/Series: Leukemia
Volume: 6
Issue: 7
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).


  • Cancer and Oncology


  • ISSN: 1476-5551
Thoas Fioretos
E-mail: thoas.fioretos [at]

Principal investigator

Division of Clinical Genetics

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