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Remarkably long survival of a patient with Ph1-positive chronic myeloid leukemia and 5' bcr rearrangement

  • Bertil Johansson
  • Fredrik Mertens
  • Thoas Fioretos
  • Sverre Heim
  • Ulf Kristoffersson
  • Nils Mandahl
  • C R Bartram
  • Felix Mitelman
Publishing year: 1990
Language: English
Pages: 448-449
Publication/Series: Leukemia
Volume: 4
Issue: 6
Document type: Journal article
Publisher: Nature Publishing Group

Abstract english

Chronic myeloid leukemia (CML) was diagnosed in a 19-year-old man in 1961, and the disease remained in chronic phase, with occasional exacerbations, for 27 years. In 1976, when the first cytogenetic analysis was performed, t(9;22)(q34;q11) was found as the sole abnormality in all mitoses. During accelerated phase in 1988, a second cytogenetic investigation showed the karyotype 45,XY,t(9;22)(q34;q11),-15,-17,+der(15) t(15;17)(p13;q11). Molecular analysis revealed a rearrangement in the 5' end of the major breakpoint cluster region (M-bcr). With the case presented here, sublocalization of the bcr breakpoint has now been undertaken in altogether five CML patients with extremely long survival. It is noteworthy that in all these cases the chromosome 22 breakpoint was located in the 5' region of the M-bcr.


  • Cancer and Oncology


  • ISSN: 1476-5551
Thoas Fioretos
E-mail: thoas.fioretos [at]

Principal investigator

Division of Clinical Genetics

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